Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia

Pediatr Blood Cancer. 2007 Mar;48(3):349-53. doi: 10.1002/pbc.20687.

Abstract

A 21-year-old white male with relapsed acute lymphoblastic leukemia (ALL) developed an invasive Zygomycosis infection 3 weeks after beginning re-induction chemotherapy. Because of the high risk of fatal recurrence of the fungal infection, neither long-term maintenance chemotherapy nor allogeneic hematopoietic stem cell transplant (HSCT) was considered appropriate. Because his ALL blasts expressed CD34 but lacked CD133, he received a CD133 selected autologous graft following high-dose consolidation chemotherapy. The patient survives in remission 19 months after HSCT.

Publication types

  • Case Reports

MeSH terms

  • AC133 Antigen
  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Antigens, CD / analysis*
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Asparaginase / administration & dosage
  • Caspofungin
  • Child
  • Combined Modality Therapy
  • Contraindications
  • Dexamethasone / administration & dosage
  • Drug Therapy, Combination
  • Echinocandins
  • Glycoproteins / analysis*
  • Humans
  • Immunomagnetic Separation
  • Lipopeptides
  • Male
  • Mercaptopurine / administration & dosage
  • Methotrexate / administration & dosage
  • Peptides / analysis*
  • Peptides, Cyclic / therapeutic use
  • Peripheral Blood Stem Cell Transplantation*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / surgery*
  • Pyrimidines / therapeutic use
  • Recurrence
  • Remission Induction
  • Salvage Therapy*
  • Transplantation, Autologous
  • Transplantation, Homologous
  • Triazoles / therapeutic use
  • Vincristine / administration & dosage
  • Voriconazole
  • Zygomycosis / complications
  • Zygomycosis / drug therapy

Substances

  • AC133 Antigen
  • Antifungal Agents
  • Antigens, CD
  • Echinocandins
  • Glycoproteins
  • Lipopeptides
  • PROM1 protein, human
  • Peptides
  • Peptides, Cyclic
  • Pyrimidines
  • Triazoles
  • liposomal amphotericin B
  • Vincristine
  • posaconazole
  • Dexamethasone
  • Amphotericin B
  • Mercaptopurine
  • Asparaginase
  • Caspofungin
  • Voriconazole
  • Methotrexate