Moxifloxacin and azithromycin but not amoxicillin protect human respiratory epithelial cells against streptococcus pneumoniae in vitro when administered up to 6 hours after challenge

Martina Ulrich; Cordula Albers; Jan-Georg Möller; Axel Dalhoff; Gisela Korfmann; Frank Künkele; Gerd Döring

doi:10.1128/AAC.49.12.5119-5122.2005

Moxifloxacin and azithromycin but not amoxicillin protect human respiratory epithelial cells against streptococcus pneumoniae in vitro when administered up to 6 hours after challenge

Antimicrob Agents Chemother. 2005 Dec;49(12):5119-22. doi: 10.1128/AAC.49.12.5119-5122.2005.

Authors

Martina Ulrich¹, Cordula Albers, Jan-Georg Möller, Axel Dalhoff, Gisela Korfmann, Frank Künkele, Gerd Döring

Affiliation

¹ Institute of Medical Microbiology and Hygiene, Universitätsklinikum Tübingen, Wilhelmstrasse 31, D-72074 Tübingen, Germany.

Abstract

We determined the protective effect of moxifloxacin, azithromycin, and amoxicillin against Streptococcus pneumoniae infection of respiratory cells. Moxifloxacin and azithromycin effectively killed intracellular S. pneumoniae strains and protected respiratory epithelial cells significantly even when given 6 h after S. pneumoniae challenge. Amoxicillin was less effective.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amoxicillin / pharmacology*
Anti-Bacterial Agents / pharmacokinetics
Anti-Bacterial Agents / pharmacology*
Aza Compounds / pharmacology*
Azithromycin / pharmacology*
Epithelial Cells / drug effects*
Epithelial Cells / microbiology
Fluoroquinolones
Humans
Moxifloxacin
Quinolines / pharmacology*
Streptococcus pneumoniae / drug effects*
Streptococcus pneumoniae / physiology

Substances

Anti-Bacterial Agents
Aza Compounds
Fluoroquinolones
Quinolines
Amoxicillin
Azithromycin
Moxifloxacin