Abstract
We investigated the in vitro and in vivo activities of caspofungin against Aspergillus terreus. The drug increased survival and reduced tissue fungal burden in neutropenic mice. Therefore, our data support the role of caspofungin in treating systemic infections due to this emerging pathogen.
MeSH terms
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Animals
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Antifungal Agents / pharmacology*
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Antifungal Agents / therapeutic use
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Aspergillosis / drug therapy*
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Aspergillosis / microbiology
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Aspergillus / classification
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Aspergillus / drug effects*
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Aspergillus / physiology
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Caspofungin
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Disease Models, Animal
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Echinocandins
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Lipopeptides
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Mice
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Microbial Sensitivity Tests
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Peptides, Cyclic / pharmacology*
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Peptides, Cyclic / therapeutic use*
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Peptides, Cyclic
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Caspofungin