Horizontal transfer of erythromycin resistance from Clostridium difficile to Butyrivibrio fibrisolvens

Antimicrob Agents Chemother. 2005 Dec;49(12):5142-5. doi: 10.1128/AAC.49.12.5142-5145.2005.

Abstract

This study demonstrates for the first time the in vitro transfer of the erythromycin resistance gene erm(B) between two obligate anaerobes, the human spore-forming pathogen Clostridium difficile and the rumen commensal Butyrivibrio fibrisolvens, suggesting that this event might occur also in the natural environment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacterial Proteins / genetics*
  • Butyrivibrio / drug effects
  • Butyrivibrio / genetics*
  • Cattle
  • Clostridioides difficile / drug effects
  • Clostridioides difficile / genetics*
  • Drug Resistance / genetics*
  • Gene Transfer, Horizontal*
  • Methyltransferases / genetics*
  • Molecular Sequence Data
  • Rumen / microbiology

Substances

  • Bacterial Proteins
  • ErmTR protein, bacteria
  • Methyltransferases

Associated data

  • GENBANK/AJ968665