Abstract
Two series of N-[5-oxo-4-(arylsulfonyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl]-amides were synthesized and tested in vivo for their analgesic and anti-inflammatory activities. All the new compounds possess good antalgic action in the acetic acid writhing test and some terms of the series showed also fair anti-inflammatory activity in the carrageenan rat paw edema test. Ulcerogenic and irritative action on the gastrointestinal mucose, in comparison with indomethacin is low.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis
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Amides / chemistry
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Analgesics / chemical synthesis
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Analgesics / chemistry*
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Analgesics / pharmacology*
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Animals
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Anti-Inflammatory Agents / chemical synthesis
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / pharmacology*
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Drug Evaluation, Preclinical
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Female
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Indomethacin / pharmacology
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Intestinal Mucosa / drug effects
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Male
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Mice
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Rats
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Stomach Ulcer / complications
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Thiadiazoles / chemical synthesis
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Thiadiazoles / chemistry*
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Thiadiazoles / pharmacology*
Substances
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Amides
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Analgesics
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Anti-Inflammatory Agents
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Thiadiazoles
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1,3,4-thiadiazole
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Indomethacin