Abstract
In this paper, we review the history, clinical, cognitive, imaging and neuropathological features of corticobasal degeneration (CBD). Additionally, we report new findings on the neuropsychological profile of 14 patients with CBD compared to 14 with Alzheimer's disease. Increasing awareness of this disorder has led to the realization that specific cognitive and imaging changes are common with CBD degeneration and that these changes help with clinical diagnosis.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Alzheimer Disease* / genetics
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Alzheimer Disease* / metabolism
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Alzheimer Disease* / pathology
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Alzheimer Disease* / therapy
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Basal Ganglia / metabolism
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Basal Ganglia / pathology
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Basal Ganglia Diseases* / genetics
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Basal Ganglia Diseases* / metabolism
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Basal Ganglia Diseases* / pathology
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Basal Ganglia Diseases* / therapy
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Biomarkers / metabolism
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Cerebral Cortex / metabolism
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Cerebral Cortex / pathology
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Cognition Disorders* / genetics
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Cognition Disorders* / metabolism
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Cognition Disorders* / pathology
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Cognition Disorders* / therapy
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Humans