Abstract
A 77-year-old male had been operated for ascending colon cancer with liver metastases. After hepatic artery injection therapy and CPT-11 plus 5'-DFUR combination therapy, oxaliplatin-based systemic chemotherapy was performed. Consequently, the tumor size was controlled for about 10 months. During the chemotherapy, we observed grade 3 neurological toxicity, but not grade 3-4 blood toxicity. Thus, the QOL of the patient was properly maintained. We conclude that the oxaliplatin-based chemotherapy may be useful for patients suffering 5-FU and CPT-11 resistant metastatic colorectal cancer in Japan.
MeSH terms
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Aged
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Antimetabolites, Antineoplastic / administration & dosage
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
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Camptothecin / administration & dosage
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Camptothecin / analogs & derivatives
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Colonic Neoplasms / drug therapy*
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Floxuridine / administration & dosage
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Humans
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Irinotecan
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Liver Neoplasms / secondary
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Male
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Organoplatinum Compounds / administration & dosage*
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Oxaliplatin
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Quality of Life
Substances
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Antimetabolites, Antineoplastic
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Antineoplastic Agents
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Antineoplastic Agents, Phytogenic
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Organoplatinum Compounds
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Floxuridine
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Oxaliplatin
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Irinotecan
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doxifluridine
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Camptothecin