Abstract
Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC50 values of 2.9 and 1.7 microM, respectively, and they also inhibited cell-mediated LDL oxidation more than five times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10 microM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor- deficient mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alnus / chemistry*
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Animals
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Antioxidants / pharmacology*
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Aorta / pathology
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Atherosclerosis / pathology
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Diarylheptanoids / chemistry
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Diarylheptanoids / pharmacology*
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Female
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Fruit / chemistry
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Lipid Peroxidation / drug effects
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Lipoproteins, LDL / metabolism*
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Mice
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Molecular Structure
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Plant Extracts / pharmacology
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Thiobarbituric Acid Reactive Substances / analysis
Substances
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Antioxidants
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Diarylheptanoids
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Lipoproteins, LDL
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Plant Extracts
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Thiobarbituric Acid Reactive Substances
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acerogenin L
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garugamblin-3