Abstract
The effects of the orally active prostacyclin mimetic cicaprost on morphologic and functional alterations of rabbit aorta was investigated in experimental hypercholesterolemia. Oral cicaprost resulted in a significantly reduced aortic atheromatous plaque formation and partially prevented hypercholesterolemia-induced impairment of endothelium-dependent relaxations. It is concluded that long-term substitution with PGI2 may beneficially influence the progression of atherosclerosis.
MeSH terms
-
Administration, Oral
-
Animals
-
Aorta, Thoracic / pathology
-
Arteriosclerosis / pathology
-
Arteriosclerosis / physiopathology
-
Arteriosclerosis / prevention & control*
-
Blood Vessels / pathology
-
Blood Vessels / physiopathology
-
Epoprostenol / administration & dosage
-
Epoprostenol / analogs & derivatives*
-
Epoprostenol / therapeutic use
-
Hypercholesterolemia / complications*
-
Lipids / blood
-
Muscle Relaxation / physiology
-
Muscle, Smooth, Vascular / physiology
-
Rabbits
Substances
-
Lipids
-
Epoprostenol
-
cicaprost