A small-molecule FRET probe to monitor phospholipase A2 activity in cells and organisms

Angew Chem Int Ed Engl. 2006 Jan 9;45(3):508-12. doi: 10.1002/anie.200500751.
No abstract available

MeSH terms

  • Animals
  • Arachidonic Acids / pharmacology
  • Cells, Cultured
  • Dogs
  • Enzyme Activation / drug effects
  • Enzyme Inhibitors / pharmacology
  • Epithelial Cells / enzymology*
  • Fluorescence Resonance Energy Transfer / methods*
  • HeLa Cells
  • Humans
  • Hydrolysis
  • Kidney / enzymology
  • Molecular Conformation
  • Molecular Weight
  • Naphthalenes / pharmacology
  • Organophosphonates / pharmacology
  • Oryzias / embryology
  • Oryzias / growth & development
  • Oryzias / metabolism*
  • Phosphatidylethanolamines / chemical synthesis
  • Phosphatidylethanolamines / chemistry*
  • Phosphatidylethanolamines / pharmacokinetics
  • Phospholipases A / antagonists & inhibitors
  • Phospholipases A / chemistry*
  • Phospholipases A2
  • Pyrones / pharmacology
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tissue Distribution

Substances

  • Arachidonic Acids
  • Enzyme Inhibitors
  • Naphthalenes
  • Organophosphonates
  • Phosphatidylethanolamines
  • Pyrones
  • methyl arachidonylfluorophosphonate
  • phosphatidylethanolamine
  • 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one
  • Phospholipases A
  • Phospholipases A2