The relevant role of zinc in osteoporosis, its correlation with nutrient intake and the modifications of its urinary and serum levels, have been demonstrated. In this paper, we have studied the plasmatic, urinary and intraerythrocitary levels of zinc in a group of patients with extended primary osteoporosis, most of them women with postmenopausic osteoporosis. No significant differences were observed in zinc levels between osteoporotic patients and controls. We think that certain aspects regarding the correlation between zinc and bone mineral content still have to be defined, as well as zinc intake and osteoporosis.