Abstract
This article is an expert review of bladder cancer genetics focusing on genetic changes and their significance in the pathogenesis and progression of bladder transitional cell carcinoma, in particular, muscle-invasive disease. Alongside the relevant genetic markers and their products, new therapeutic targets and agents that are being developed are presented.
MeSH terms
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Carcinoma, Transitional Cell / genetics*
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Carcinoma, Transitional Cell / pathology*
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Cell Transformation, Neoplastic / genetics
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Disease Progression
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Genetic Markers
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Humans
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Neoplasm Invasiveness
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Neoplasm Metastasis / genetics
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Neoplasm Metastasis / physiopathology*
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Neovascularization, Pathologic
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Urinary Bladder Neoplasms / genetics*
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Urinary Bladder Neoplasms / pathology*