Abstract
In various eukaryotes, sterol-rich membrane domains have been proposed to play an important role in polarization and compartmentalization of the plasma membrane. Several studies have reported the cellular distribution of sterols in genetically tractable yeast species and the identification of molecules that might regulate the localization of sterol-rich membrane domains. Here, we attempt to synthesize our understanding of the function and organization of these domains from the study of fungi and identify some outstanding issues.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Candida albicans / physiology
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Candida albicans / ultrastructure
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Cell Membrane / drug effects
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Cell Membrane / physiology
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Cell Membrane / ultrastructure
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Cell Polarity
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Cryptococcus neoformans / physiology
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Cryptococcus neoformans / ultrastructure
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Cytoskeletal Proteins / analysis
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Filipin
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Lipids / analysis
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Membrane Microdomains / chemistry
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Membrane Microdomains / physiology*
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Membrane Microdomains / ultrastructure*
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Octoxynol / pharmacology
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Protein Transport
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Pyridinium Compounds
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Quaternary Ammonium Compounds
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Saccharomyces cerevisiae / physiology
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Saccharomyces cerevisiae / ultrastructure
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Schizosaccharomyces / physiology
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Schizosaccharomyces / ultrastructure
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Signal Transduction
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Sterols / analysis
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Yeasts / physiology*
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Yeasts / ultrastructure*
Substances
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Cytoskeletal Proteins
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FM 4-64
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Lipids
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Pyridinium Compounds
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Quaternary Ammonium Compounds
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Sterols
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Filipin
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Octoxynol