Clostridium asparagiforme sp. nov., isolated from a human faecal sample

Syst Appl Microbiol. 2006 Jun;29(4):292-9. doi: 10.1016/j.syapm.2005.11.001. Epub 2005 Dec 7.

Abstract

An obligatory anaerobic, Gram-positive, rod-shaped organism was isolated from faeces of a healthy human donor. It was characterized using biochemical, phenotypic and molecular taxonomic methods. The organism produced acetate, lactate, and ethanol as the major products of glucose fermentation. The G + C content was 53 mol%. Based on comparative 16S rRNA gene sequencing, the unidentified bacterium is a member of the Clostridium subphylum of the Gram-positive bacteria, and most closely related to species of the Clostridium coccoides cluster (rRNA cluster XIVa) [M.D. Collins et al., The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species combinations, Int. J. Syst. Bacteriol. 44 (1994) 812-826]. Clostridium bolteae and Clostridium clostridioforme were identified as the most closely related described species. A 16S rRNA sequence divergence value of > 3% suggested that the isolate represents a new species. This was also supported by the gyrase-encoding gyrB gene sequences. Based on these findings, we propose the novel bacterium from human faeces to be classified as a new species, Clostridium asparagiforme. The type strain of C. asparagiforme is N6 (DSM 15981 and CCUG 48471).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid / metabolism
  • Anaerobiosis
  • Bacterial Proteins / genetics
  • Bacterial Typing Techniques
  • Base Composition
  • Clostridium / classification*
  • Clostridium / cytology
  • Clostridium / isolation & purification*
  • Clostridium / physiology
  • Clostridium Infections / microbiology
  • DNA Gyrase / genetics
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • Ethanol / metabolism
  • Fatty Acids / analysis
  • Fatty Acids / isolation & purification
  • Feces / microbiology*
  • Genes, rRNA / genetics
  • Gentian Violet
  • Glucose / metabolism
  • Humans
  • Lactic Acid / metabolism
  • Microscopy, Electron, Scanning
  • Molecular Sequence Data
  • Phenazines
  • Phylogeny
  • RNA, Bacterial / genetics
  • RNA, Ribosomal, 16S / genetics
  • Sequence Analysis, DNA

Substances

  • Bacterial Proteins
  • DNA, Bacterial
  • DNA, Ribosomal
  • Fatty Acids
  • Gram's stain
  • Phenazines
  • RNA, Bacterial
  • RNA, Ribosomal, 16S
  • Lactic Acid
  • Ethanol
  • DNA Gyrase
  • Glucose
  • Gentian Violet
  • Acetic Acid

Associated data

  • GENBANK/AJ582080
  • GENBANK/DQ093418
  • GENBANK/DQ093419
  • GENBANK/DQ093420