In-line (18)F-fluorodeoxyglucose positron emission tomography with computed tomography (PET/CT) in patients with carcinoma of the sinus/nasal area and orbit

J Craniomaxillofac Surg. 2006 Jan;34(1):9-16. doi: 10.1016/j.jcms.2005.08.001. Epub 2005 Dec 15.

Abstract

Background: Contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) are the standard imaging techniques to evaluate patients with carcinoma in the sinus/nasal area and orbit. The use of positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) in such patients is as yet less well established.

Purpose: The aim of this study was to assess the clinical impact of PET co-registered with CT (PET/CT).

Patients: Evaluation of 21 consecutive patients.

Methods: A retrospective analysis of the whole body PET/CT studies was done. Images were assessed visually without knowing the results of the other imaging technique. Histology and clinical follow-up served to verify lesions. The clinical impact on therapy was assessed together with the physician in charge.

Results: All patients underwent PET/CT and CT or MRI for staging (n=9 scans) and restaging (n=17 scans) without treatment between the examinations. PET/CT changed the treatment protocol in 2 patients at staging and in 7 at re-staging. Distant metastases were found in 5 and a secondary tumour in 1 patient.

Conclusions: Whole body PET/CT adds clinically important information to CT or MRI, thus, influencing treatment.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma / diagnosis*
  • Carcinoma / pathology
  • Female
  • Fluorodeoxyglucose F18*
  • Follow-Up Studies
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Staging
  • Neoplasm, Residual / diagnosis
  • Neoplasms, Second Primary / diagnosis
  • Nose Neoplasms / diagnosis*
  • Nose Neoplasms / pathology
  • Orbital Neoplasms / diagnosis*
  • Orbital Neoplasms / pathology
  • Paranasal Sinus Neoplasms / diagnosis*
  • Paranasal Sinus Neoplasms / pathology
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals*
  • Retrospective Studies
  • Tomography, Spiral Computed / methods*
  • Whole Body Imaging

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18