Abstract
Four compounds, including two novel macrolides, were isolated from an endophyte Streptomyces sp. Is9131 of Maytenus hookeri. Spectral data indicated that these compounds were dimeric dinactin (1), dimeric nonactin (2), cyclo-homononactic acid (3), and cyclo-nonactic acid (4). Bioassay results showed that dimeric dinactin had strong antineoplastic activity and antibacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Antibiotics, Antineoplastic / chemistry*
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Antibiotics, Antineoplastic / pharmacology*
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Bacteria / drug effects
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Macrolides / chemistry*
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Macrolides / pharmacology*
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
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Streptomyces / chemistry*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Macrolides
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dinactin