Abstract
This study assessed compatibility of concurrently administered 7-valent pneumococcal conjugate (PCV7), hepatitis B (HB) and DTaP.IPV/Hib vaccines. Infants were given DTaP.IPV/Hib and HB at 2, 4, 6 months and randomly assigned (2:1) to receive PCV7 concurrently or sequentially (at 3, 5, 7 months). Antibody levels were compared in 246 concurrent and 122 sequential vaccinees. Responses to PCV7, DTaP.IPV/Hib and HB were generally unaltered with concurrent administration except that Hib responses were increased (p=0.008) and HB responses were reduced (p=0.006) with concurrent dosing, the latter possibly from same thigh injection with DTaP.IPV/Hib. We conclude that PCV7, DTaP.IPV/Hib and HB are compatible with concurrent, separate injections.
Publication types
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Clinical Trial, Phase IV
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Randomized Controlled Trial
MeSH terms
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Antibodies, Bacterial / analysis
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Antibodies, Bacterial / biosynthesis
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Antibodies, Viral / analysis
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Antibodies, Viral / biosynthesis
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Bacterial Capsules
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Diphtheria-Tetanus-acellular Pertussis Vaccines / administration & dosage*
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Diphtheria-Tetanus-acellular Pertussis Vaccines / adverse effects
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Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology
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Haemophilus Vaccines / administration & dosage*
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Haemophilus Vaccines / adverse effects
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Haemophilus Vaccines / immunology
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Hepatitis B Vaccines / administration & dosage*
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Hepatitis B Vaccines / adverse effects
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Hepatitis B Vaccines / immunology
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Humans
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Immunization Schedule
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Infant
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Pneumococcal Vaccines / administration & dosage*
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Pneumococcal Vaccines / adverse effects
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Pneumococcal Vaccines / immunology
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Poliovirus Vaccine, Inactivated / administration & dosage*
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Poliovirus Vaccine, Inactivated / adverse effects
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Poliovirus Vaccine, Inactivated / immunology
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Polysaccharides, Bacterial / administration & dosage*
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Polysaccharides, Bacterial / adverse effects
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Polysaccharides, Bacterial / immunology
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Safety
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Vaccines, Combined / adverse effects
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Vaccines, Combined / immunology
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Vaccines, Conjugate / administration & dosage
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Vaccines, Conjugate / immunology
Substances
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Antibodies, Bacterial
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Antibodies, Viral
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Diphtheria-Tetanus-acellular Pertussis Vaccines
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Haemophilus Vaccines
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Haemophilus influenzae type b polysaccharide vaccine
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Hepatitis B Vaccines
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Pneumococcal Vaccines
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Poliovirus Vaccine, Inactivated
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Polysaccharides, Bacterial
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Vaccines, Combined
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Vaccines, Conjugate