Abstract
The effect of moderate and intensive lipid lowering on plaque progression and arterial remodeling at coronary branch points was investigated. Intensive (+1 +/- 19.6%), but not moderate (+4.1 +/- 15.1%), lipid lowering prevented an increase in the percent [corrected] plaque area at the branch points. The 2 strategies were associated with increased areas of the lumen (+7.6% to 9.4%) and external elastic membrane (+9.6% to 10.8%). In contrast, there was no significant change in plaque, lumen, and/or external elastic membrane areas at the nonbranch point site. These results suggest that intensive lipid lowering can have a dramatic effect on atheroma-prone regions and that remodeling in response to changes in plaque is a heterogenous process.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Anticholesteremic Agents / administration & dosage
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Anticholesteremic Agents / therapeutic use*
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Atorvastatin
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Cholesterol, LDL / blood
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Coronary Angiography
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Coronary Artery Disease / blood
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Coronary Artery Disease / diagnosis
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Coronary Artery Disease / drug therapy*
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Coronary Vessels / diagnostic imaging
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Coronary Vessels / drug effects*
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Dose-Response Relationship, Drug
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Female
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Follow-Up Studies
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Heptanoic Acids / administration & dosage
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Heptanoic Acids / therapeutic use*
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Humans
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Male
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Middle Aged
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Pravastatin / administration & dosage
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Pravastatin / therapeutic use*
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Pyrroles / administration & dosage
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Pyrroles / therapeutic use*
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Treatment Outcome
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Ultrasonography, Interventional
Substances
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Anticholesteremic Agents
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Cholesterol, LDL
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Heptanoic Acids
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Pyrroles
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Atorvastatin
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Pravastatin