Corpus callosum functioning in patients with normal pressure hydrocephalus before and after surgery

J Neurol. 2006 May;253(5):625-30. doi: 10.1007/s00415-005-0073-z. Epub 2005 Dec 13.

Abstract

Objectives: Our aim was to evaluate corpus callosum functioning in a group of patients with normal pressure hydrocephalus (NPH) before and after shunting.

Methods: Left ear-extinction under a dichotic listening task was evaluated in twenty-three patients with NPH, 30 patients with Alzheimer's disease and 30 aged controls.

Results: Patients with NPH had higher levels of left ear extinction than the control and Alzheimer's groups. Sixty-one percent of NPH patients exhibited left ear suppression, compared with 13% of Alzheimer's patients and 17% of controls. Following surgery, NPH patients showed a significant change in the degree of asymmetry in the dichotic listening task.

Conclusions: Hydrocephalus was associated with left-ear extinction,which diminished after surgery. Our results may indicate reversible functional damage in the corpus callosum.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Analysis of Variance
  • Auditory Perception / physiology
  • Cerebrospinal Fluid Shunts / methods*
  • Corpus Callosum / physiopathology*
  • Dichotic Listening Tests / methods
  • Female
  • Functional Laterality
  • Humans
  • Hydrocephalus, Normal Pressure / etiology
  • Hydrocephalus, Normal Pressure / pathology*
  • Hydrocephalus, Normal Pressure / surgery*
  • Male
  • Middle Aged
  • Parkinson Disease / complications
  • Parkinson Disease / surgery
  • Retrospective Studies