Abstract
Delayed methotrexate (MTX) elimination occurred in two patients with primary central nervous system lymphoma undergoing high-dose MTX treatment. Oral administration of the anion exchange resin colestimide, which binds MTX effectively in vitro, effectively accelerated MTX elimination. Colestimide probably interrupts the enterohepatic circulation, and is a potential oral antidote to MTX toxicity.
MeSH terms
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Administration, Oral
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Adult
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Antimetabolites, Antineoplastic / pharmacokinetics*
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Central Nervous System Neoplasms / drug therapy*
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Epichlorohydrin / administration & dosage
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Epichlorohydrin / pharmacology*
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Humans
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Imidazoles / administration & dosage
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Imidazoles / pharmacology*
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Lymphoma / drug therapy*
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Male
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Methotrexate / administration & dosage
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Methotrexate / pharmacokinetics*
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Middle Aged
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Resins, Synthetic / administration & dosage
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Resins, Synthetic / pharmacology*
Substances
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Antimetabolites, Antineoplastic
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Imidazoles
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Resins, Synthetic
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colestimide
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Epichlorohydrin
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Methotrexate