Antiangiogenic activity of deoxoartemisinin derivatives on chorioallantoic membrane

Mankil Jung; Jungae Tak; Won-Yoon Chung; Kwang-Kyun Park

doi:10.1016/j.bmcl.2005.11.074

Antiangiogenic activity of deoxoartemisinin derivatives on chorioallantoic membrane

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1227-30. doi: 10.1016/j.bmcl.2005.11.074. Epub 2005 Dec 27.

Authors

Mankil Jung¹, Jungae Tak, Won-Yoon Chung, Kwang-Kyun Park

Affiliation

¹ Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea. [email protected]

PMID: 16380253
DOI: 10.1016/j.bmcl.2005.11.074

Abstract

Non acetal-type derivatives at C-12 of artemisinin and their novel dimers including a fullerene conjugate were synthesized and some of them showed potent in vivo antiangiogenic activity on chorioallantoic membrane higher than or comparable to those of fumagillin and thalidomide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetals / chemistry
Angiogenesis Inhibitors / chemical synthesis*
Angiogenesis Inhibitors / chemistry
Angiogenesis Inhibitors / pharmacology*
Animals
Artemisinins / chemical synthesis
Artemisinins / chemistry*
Artemisinins / pharmacology*
Chick Embryo
Chorioallantoic Membrane / blood supply*
Chorioallantoic Membrane / drug effects*
Molecular Structure
Sesquiterpenes / chemical synthesis
Sesquiterpenes / chemistry*
Sesquiterpenes / pharmacology*
Structure-Activity Relationship

Substances

Acetals
Angiogenesis Inhibitors
Artemisinins
Sesquiterpenes
deoxoartemisinin