Abstract
The Myc family of oncoproteins are thought to regulate proliferation and differentiation in a wide variety of cell types. Recent studies show that Myc proteins form sequence-specific DNA-binding complexes with Max, a new member of the helix-loop-helix leucine zipper protein class. The properties of the Myc-Max complex suggest a mechanism for Myc's function in both normal and neoplastic cell behavior.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Basic-Leucine Zipper Transcription Factors
-
DNA-Binding Proteins / chemistry
-
DNA-Binding Proteins / physiology*
-
Gene Expression Regulation / physiology
-
Nucleoproteins / chemistry
-
Proto-Oncogene Proteins c-myc / chemistry
-
Proto-Oncogene Proteins c-myc / physiology*
-
Transcription Factors*
Substances
-
Basic-Leucine Zipper Transcription Factors
-
DNA-Binding Proteins
-
Myc associated factor X
-
Nucleoproteins
-
Proto-Oncogene Proteins c-myc
-
Transcription Factors