Loss of chromosome 22 in patients with refractory anemia with excess of blasts (RAEB) in transformation and acute leukemia after RAEB

R Berger; M Le Coniat; J Derré; M A Flexor

doi:10.1016/0165-4608(92)90090-u

Loss of chromosome 22 in patients with refractory anemia with excess of blasts (RAEB) in transformation and acute leukemia after RAEB

Cancer Genet Cytogenet. 1992 Jul 15;61(2):210-2. doi: 10.1016/0165-4608(92)90090-u.

Authors

R Berger¹, M Le Coniat, J Derré, M A Flexor

Affiliation

¹ Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.

PMID: 1638507
DOI: 10.1016/0165-4608(92)90090-u

Abstract

We report studies of 12 patients with refractory anemia and excess of blasts in transformation (RAEB-t) and 17 with acute myeloblastic leukemia (AML) after RAEB. Besides chromosome 5 and 7 abnormalities, five patients with complex karyotypic changes had monosomy 22. This association is discussed in relation to the hypothesis of a suppressor gene located on chromosome 22.

MeSH terms

Adult
Aged
Anemia, Refractory, with Excess of Blasts / genetics*
Anemia, Refractory, with Excess of Blasts / pathology
Blast Crisis / genetics*
Blast Crisis / pathology
Chromosome Aberrations
Chromosomes, Human, Pair 22*
Female
Humans
Leukemia, Myeloid, Acute / genetics*
Male
Middle Aged
Monosomy*