Positive selection can create false hotspots of recombination

Floyd A Reed; Sarah A Tishkoff

doi:10.1534/genetics.105.052183

Positive selection can create false hotspots of recombination

Genetics. 2006 Mar;172(3):2011-4. doi: 10.1534/genetics.105.052183. Epub 2005 Dec 30.

Authors

Floyd A Reed¹, Sarah A Tishkoff

Affiliation

¹ Department of Biology, University of Maryland, College Park, Maryland 20742, USA. [email protected]

Abstract

Simulations of positive directional selection, under parameter values appropriate for approximating human genetic diversity and rates of recombination, reveal that the effects of strong selective sweeps on patterns of linkage disequilibrium (LD) mimic the pattern expected with recombinant hotspots.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Computer Simulation*
Humans
Linkage Disequilibrium
Meiosis* / genetics
Models, Genetic
Recombination, Genetic*
Selection, Genetic
Species Specificity