Abstract
Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs--metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL-7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Cell Line
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Chemical Fractionation / methods
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Chloroform / chemistry
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HL-60 Cells
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Humans
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Mice
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Molecular Structure
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Pigments, Biological / chemistry
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Pigments, Biological / isolation & purification
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Pigments, Biological / pharmacology
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Porifera / microbiology
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Prodigiosin / analogs & derivatives*
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Prodigiosin / chemistry
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Prodigiosin / isolation & purification
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Prodigiosin / pharmacology
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Saccharopolyspora / chemistry*
Substances
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Antineoplastic Agents
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Pigments, Biological
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metacycloprodigiosin
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undecylprodigiosin
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Chloroform
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Prodigiosin