Dihydrotrichodimerol and tetrahydrotrichodimerol, two new bisorbicillinoids, from a marine-derived Penicillium terrestre

Weizhong Liu; Qianqun Gu; Weiming Zhu; Chengbin Cui; Guotao Fan

doi:10.1038/ja.2005.85

Dihydrotrichodimerol and tetrahydrotrichodimerol, two new bisorbicillinoids, from a marine-derived Penicillium terrestre

J Antibiot (Tokyo). 2005 Oct;58(10):621-4. doi: 10.1038/ja.2005.85.

Authors

Weizhong Liu¹, Qianqun Gu, Weiming Zhu, Chengbin Cui, Guotao Fan

Affiliation

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, PR China.

PMID: 16392677
DOI: 10.1038/ja.2005.85

Abstract

Two new bisorbicillinoids possessing an open-ended cage structure, dihydrotrichodimerol (1) and tetrahydrotrichodimerol (2), were isolated from a marine-derived Penicillium terrestre. Their structures were established by spectroscopic methods. Their cytotoxic activities against P388 and A-549 cell lines were preliminarily evaluated by the MTT method.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bridged-Ring Compounds / chemistry
Bridged-Ring Compounds / isolation & purification*
Bridged-Ring Compounds / pharmacology
Cell Line
Marine Biology
Penicillium / chemistry*

Substances

Bridged-Ring Compounds
bisorbicillinolide
tetrahydrotrichodimerol