Abstract
Using whole genome expression microarray technology to discover clinically relevant biomarkers for pilocytic astrocytoma (PA), the authors identified matrilin-2 as a unique mRNA overexpressed in PA. Matrilin-2 protein expression was similarly elevated in the majority of sporadic PA, but in only one neurofibromatosis 1-associated PA with an unusually aggressive clinical phenotype. These results suggest that matrilin-2 may be a specific and clinically useful biomarker for discriminating between indolent and clinically aggressive PA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Astrocytoma / classification
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Astrocytoma / diagnosis*
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Astrocytoma / genetics*
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Biomarkers, Tumor / genetics*
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Brain Neoplasms / diagnosis*
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Brain Neoplasms / genetics*
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Cell Transformation, Neoplastic / genetics
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Child
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Chromosomes, Human, Pair 8 / genetics
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DNA Mutational Analysis
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Extracellular Matrix Proteins / genetics*
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Extracellular Matrix Proteins / metabolism
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic / genetics
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Genetic Testing
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Glycoproteins / genetics*
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Glycoproteins / metabolism
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Humans
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Immunohistochemistry
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Matrilin Proteins
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Neurofibromatosis 1 / complications
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Neurofibromatosis 1 / genetics
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Oligonucleotide Array Sequence Analysis
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RNA, Messenger / analysis
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RNA, Messenger / genetics
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Up-Regulation / genetics
Substances
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Biomarkers, Tumor
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Extracellular Matrix Proteins
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Glycoproteins
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MATN2 protein, human
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Matrilin Proteins
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RNA, Messenger