Strategies for the treatment of acute promyelocytic leukemia

J Natl Compr Canc Netw. 2006 Jan;4(1):37-50. doi: 10.6004/jnccn.2006.0005.

Abstract

The outcome of acute promyelocytic leukemia (APL) has improved dramatically during the past 40 years. Insights into the genetic and biologic mechanisms of APL lead to the development of specific and effective therapeutic strategies. This article discusses the therapeutic interventions that transformed APL from one of the most lethal leukemias to one that is highly curable.

Publication types

  • Review

MeSH terms

  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / adverse effects
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Arsenic Trioxide
  • Arsenicals / adverse effects
  • Arsenicals / therapeutic use
  • Humans
  • Leukemia, Promyelocytic, Acute / diagnosis
  • Leukemia, Promyelocytic, Acute / drug therapy*
  • Leukemia, Promyelocytic, Acute / genetics
  • Oxides / adverse effects
  • Oxides / therapeutic use
  • Treatment Outcome
  • Tretinoin / administration & dosage
  • Tretinoin / adverse effects

Substances

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Arsenicals
  • Oxides
  • Tretinoin
  • Arsenic Trioxide