A novel convenient synthesis of benzoquinazolines

Org Lett. 2006 Jan 19;8(2):255-6. doi: 10.1021/ol052594m.

Abstract

[reaction: see text] A novel synthetic pathway to benzoquinazolines from naphthylamines is reported. Benzoquinazoline nucleus was cyclized in good yield from N-protected naphthylamines using hexamethylenetetramine in TFA and potassium ferricyanide in aqueous ethanolic KOH. This method is efficient and convenient with respect to previously reported synthetic pathways.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Naphthylamine / analogs & derivatives*
  • 2-Naphthylamine / chemistry*
  • Benzene Derivatives / chemical synthesis*
  • Catalysis
  • Cyclization
  • Indicators and Reagents
  • Molecular Structure
  • Quinazolines / chemical synthesis*

Substances

  • Benzene Derivatives
  • Indicators and Reagents
  • Quinazolines
  • 2-Naphthylamine