[Farquhar disease. Reduced phagocyte function in a 9-year-old girl with erythrophagocytic lymphohistiocytosis]

H Schroten; A Kampmann; M Sperzel; H Jürgens; R Seger; V Wahn

[Farquhar disease. Reduced phagocyte function in a 9-year-old girl with erythrophagocytic lymphohistiocytosis]

Monatsschr Kinderheilkd. 1992 Jun;140(6):336-9.

[Article in German]

Authors

H Schroten¹, A Kampmann, M Sperzel, H Jürgens, R Seger, V Wahn

Affiliation

¹ Zentrum für Kinderheilkunde, Heinrich-Heine-Universität Düsseldorf.

PMID: 1640943

Abstract

We report phagocyte function tests in a female infant with familial hemophagozytotic lymphohistiocytosis. Chemiluminescence and killing of Saccharomyces cerevisiae by monocytes and granulocytes before chemotherapy and in remission were examined. Patients' monocytes and granulocytes showed a markedly reduced chemiluminescence and killing capacity irrespective of the stage of disease.

Publication types

Case Reports

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Erythrocytes / immunology
Female
Granulocytes / drug effects
Granulocytes / immunology
Histiocytes / drug effects
Histiocytes / immunology
Histiocytosis, Non-Langerhans-Cell / drug therapy
Histiocytosis, Non-Langerhans-Cell / genetics*
Histiocytosis, Non-Langerhans-Cell / immunology
Humans
Infant
Luminescent Measurements
Monocytes / drug effects
Monocytes / immunology
Phagocytes / drug effects
Phagocytes / immunology*
Phagocytosis / drug effects
Phagocytosis / genetics*
Phagocytosis / immunology
Saccharomyces cerevisiae / immunology