[Low-dose weekly paclitaxel therapy proved useful for a case of recurrent gastric cancer with clinically latent hepatic cirrhosis]

Gan To Kagaku Ryoho. 2006 Jan;33(1):105-7.
[Article in Japanese]

Abstract

The patient was a 68-year-old-man who suffered from recurrent peritoneal gastric cancer. He was initially treated with TS-1 as an outpatient. However, his serum CEA level elevated in March 2004, and he complained of epigastric pain in June. A chest and abdominal CT revealed lung and local recurrence. He began weekly paclitaxel as second-line chemotherapy in September. Paclitaxel was infused once a week for two weeks as one cycle, at a dose of 60 mg because of the clinically latent hepatic cirrhosis. One month after the first infusion therapy, epigastric pain was greatly reduced. A CT scan showed the lung metastasis had disappeared and the size of the tumor around the anastomosis was reduced to 50% after 2 months. The toxic events were appetite loss (grade 2) and alopecia (grade 2).

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Anastomosis, Roux-en-Y
  • Antineoplastic Agents, Phytogenic / administration & dosage*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Gastrectomy
  • Humans
  • Liver Cirrhosis / complications*
  • Male
  • Neoplasm Invasiveness
  • Paclitaxel / administration & dosage*
  • Peritoneal Neoplasms / pathology
  • Stomach Neoplasms / complications
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / surgery

Substances

  • Antineoplastic Agents, Phytogenic
  • Paclitaxel