An SDF-1 trap for myeloid cells stimulates angiogenesis

Carmen Ruiz de Almodovar; Aernout Luttun; Peter Carmeliet

doi:10.1016/j.cell.2005.12.023

An SDF-1 trap for myeloid cells stimulates angiogenesis

Cell. 2006 Jan 13;124(1):18-21. doi: 10.1016/j.cell.2005.12.023.

Authors

Carmen Ruiz de Almodovar¹, Aernout Luttun, Peter Carmeliet

Affiliation

¹ The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B-3000 Leuven, Belgium.

PMID: 16413476
DOI: 10.1016/j.cell.2005.12.023

Abstract

In this issue of Cell, Grunewald et al. (2005) examine the role of hematopoietic cells in the formation of new blood vessels. They show that organ-specific expression of vascular endothelial growth factor (VEGF) is sufficient to mobilize and recruit hematopoietic cells from the bone marrow to the blood, but retention of the proangiogenic subpopulation of hematopoietic cells in peripheral organs requires an additional factor, stromal-derived factor 1 (SDF-1).

Publication types

Comment
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chemokine CXCL12
Chemokines, CXC / physiology*
Hematopoietic Stem Cells / drug effects
Hematopoietic Stem Cells / physiology
Myeloid Cells / drug effects
Myeloid Cells / physiology*
Neovascularization, Physiologic / drug effects
Neovascularization, Physiologic / physiology*
Vascular Endothelial Growth Factor A / pharmacology
Vascular Endothelial Growth Factor A / physiology

Substances

Chemokine CXCL12
Chemokines, CXC
Vascular Endothelial Growth Factor A