Anti-IgG autoantibodies in HIV-infected hemophilia patients

Vox Sang. 1992;62(4):224-9. doi: 10.1111/j.1423-0410.1992.tb01203.x.

Abstract

Sera of 76 HIV-negative hemophilia patients, 103 HIV-positive (HIV+) hemophilia patients free of AIDS or AIDS related complex (ARC), and 32 HIV+ hemophilia patients with AIDS/ARC were tested for four different anti-IgG activities. IgG-anti-F(ab')2 gamma, IgM-anti-F(ab')2 gamma, and IgG-anti-Fc gamma serum activities were significantly associated with the clinical stage of HIV infection, whereas IgM-anti-Fc gamma was not. IgG-anti-F(ab')2 gamma activity was found to be caused by cross-reaction of anti-HIV antibody with an epitope within the constant CH1 domain of human IgG. HIV+ hemophilia patients with severe thrombocytopenia (less than 50,000/microliters platelet counts) had significantly higher IgM-anti-IgG activity than patients with greater than 50,000/microliters platelets. Because anti-IgG antibodies possess immunoregulatory properties, our results may serve as a possible explanation for the frequent B cell disorders encountered in HIV-infected patients.

Publication types

  • Comparative Study

MeSH terms

  • AIDS-Related Complex / blood
  • AIDS-Related Complex / complications
  • AIDS-Related Complex / immunology
  • Acquired Immunodeficiency Syndrome / blood
  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / immunology
  • Agammaglobulinemia / etiology
  • Agammaglobulinemia / immunology
  • Amino Acid Sequence
  • Antibodies, Anti-Idiotypic / blood*
  • Antibodies, Anti-Idiotypic / immunology
  • Autoantibodies / blood*
  • Autoantibodies / immunology
  • B-Lymphocytes / immunology
  • Cross Reactions
  • Genes, Immunoglobulin
  • HIV Envelope Protein gp120 / immunology
  • HIV Infections / blood
  • HIV Infections / complications
  • HIV Infections / immunology*
  • Hemophilia A / blood
  • Hemophilia A / complications
  • Hemophilia A / immunology*
  • Humans
  • Immunoglobulin Fab Fragments / immunology
  • Immunoglobulin Fc Fragments / immunology
  • Immunoglobulin G / immunology*
  • Immunoglobulin M / blood
  • Immunoglobulin M / immunology
  • Molecular Sequence Data
  • Sequence Homology, Nucleic Acid
  • Thrombocytopenia / blood
  • Thrombocytopenia / complications
  • Thrombocytopenia / immunology

Substances

  • Antibodies, Anti-Idiotypic
  • Autoantibodies
  • HIV Envelope Protein gp120
  • Immunoglobulin Fab Fragments
  • Immunoglobulin Fc Fragments
  • Immunoglobulin G
  • Immunoglobulin M