Collaboration between clinical laboratories in different countries is widespread but rarely subject to critical analysis. We developed a management tool for assessing the quality of an international pathology laboratory collaboration. Key areas of activity were identified and relevant performance indicators were established. There was no evidence of improved staff morale arising from the project but research, education, equipment, protocols and ethics activities all had demonstrable outputs. Identification of suboptimal performance in areas of the project allowed effective improvement planning. International collaboration may consume significant resources. Objective assessment should be used to measure performance and to enhance quality.