Abstract
Type 1 fimbrial phase-locked mutants of uropathogenic Escherichia coli cystitis isolate F11 were used to assess the role of the invertible element during urinary tract infection. Compared to the wild type, the phase-locked off mutant was attenuated, and constitutive production of type 1 fimbriae by the phase-locked on mutant did not provide a competitive advantage.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Colony Count, Microbial
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Cystitis / microbiology
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Escherichia coli / classification*
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Escherichia coli / genetics
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Escherichia coli / growth & development
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Escherichia coli / pathogenicity*
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Escherichia coli Infections / microbiology
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism
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Female
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Fimbriae, Bacterial / genetics
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Fimbriae, Bacterial / metabolism*
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Gene Expression Regulation, Bacterial*
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Humans
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Kidney / microbiology
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Mice
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Mice, Inbred CBA
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Mutation
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Urinary Bladder / microbiology
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Urinary Tract Infections / microbiology*
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Urine / microbiology
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Virulence
Substances
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Escherichia coli Proteins