Abstract
A series of analogues related to picobenzide (CAS 51832-87-2) have been prepared and have been used as starting material to obtain new trisubstituted oxazole derivatives. Two compounds showed a promising pharmacological profile in screening tests of antipsychotic activity, since they affected apomorphine-induced hyperactivity without significant effects on stereotypies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antipsychotic Agents / chemical synthesis*
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Antipsychotic Agents / pharmacology*
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Apomorphine / antagonists & inhibitors
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Apomorphine / pharmacology
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Behavior, Animal / drug effects
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Benzamides / chemical synthesis*
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Benzamides / pharmacology*
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Dopamine Agonists / pharmacology
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Drug Evaluation, Preclinical
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Hyperkinesis / chemically induced
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Hyperkinesis / prevention & control
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Indicators and Reagents
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Male
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Mice
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Motor Activity / drug effects
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Rats
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Rats, Sprague-Dawley
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Stereotyped Behavior / drug effects
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Structure-Activity Relationship
Substances
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Antipsychotic Agents
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Benzamides
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Dopamine Agonists
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Indicators and Reagents
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picobenzide
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Apomorphine