Abstract
[reaction: see text]. An N-S acyl-transfer-mediated preparation of peptide thioesters using the S-protected oxazolidinone derived from cysteine has been developed and applied to the synthesis of a 32-mer biologically active peptide by native chemical ligation protocols.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cysteine / chemistry*
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Esters
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Molecular Structure
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Oxazolidinones / chemical synthesis*
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Oxazolidinones / chemistry*
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Peptides / chemical synthesis*
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Peptides / chemistry
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Sulfur Compounds / chemical synthesis*
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Sulfur Compounds / chemistry
Substances
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Esters
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Oxazolidinones
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Peptides
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Sulfur Compounds
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Cysteine