PCR classification of CTX-M-type beta-lactamase genes identified in clinically isolated gram-negative bacilli in Japan

Naohiro Shibata; Hiroshi Kurokawa; Yohei Doi; Tetsuya Yagi; Kunikazu Yamane; Jun-ichi Wachino; Satowa Suzuki; Kouji Kimura; Satoshi Ishikawa; Haru Kato; Yoshiyuki Ozawa; Keigo Shibayama; Kumiko Kai; Toshifumi Konda; Yoshichika Arakawa

doi:10.1128/AAC.50.2.791-795.2006

PCR classification of CTX-M-type beta-lactamase genes identified in clinically isolated gram-negative bacilli in Japan

Antimicrob Agents Chemother. 2006 Feb;50(2):791-5. doi: 10.1128/AAC.50.2.791-795.2006.

Authors

Naohiro Shibata¹, Hiroshi Kurokawa, Yohei Doi, Tetsuya Yagi, Kunikazu Yamane, Jun-ichi Wachino, Satowa Suzuki, Kouji Kimura, Satoshi Ishikawa, Haru Kato, Yoshiyuki Ozawa, Keigo Shibayama, Kumiko Kai, Toshifumi Konda, Yoshichika Arakawa

Affiliation

¹ Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo, Japan.

Abstract

Of 1,456 strains isolated from 2001 to 2003 demonstrating resistance to either oxyimino-cephalosporin, 317 strains, isolated in 57 of 132 clinical facilities, were found to harbor bla(CTX-M) genes by PCR. Fifty-seven, 161, and 99 strains harbored bla(CTX-M) genes belonging to the bla(CTX-M-1), bla(CTX-M-2), and bla(CTX-M-9) clusters, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Escherichia coli Proteins / genetics*
Gram-Negative Bacteria / enzymology*
Humans
beta-Lactamases / genetics*

Substances

Escherichia coli Proteins
CTX-M-9 protein, E coli
beta-lactamase CTX-2
beta-lactamase TEM-3
beta-Lactamases