Abstract
Synthesis, conformational analysis and antitumor evaluation of 2'- and 3'-C-methyl analogues of mizoribine (bredinine, 4-carbamoyl-1-beta-D-ribofuranosylimidazole-5-olate) are reported.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antineoplastic / chemical synthesis*
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Antibiotics, Antineoplastic / pharmacology
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Drug Evaluation, Preclinical
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacokinetics
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Humans
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IMP Dehydrogenase / antagonists & inhibitors*
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K562 Cells
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Molecular Structure
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Ribonucleosides / chemical synthesis*
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Ribonucleosides / pharmacology
Substances
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Antibiotics, Antineoplastic
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Enzyme Inhibitors
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Ribonucleosides
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mizoribine
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IMP Dehydrogenase