Abstract
In the German Breast Cancer Study Group (GBSG) multicenter trial "Breast preservation in small breast cancer" 1119 patients were accrued over a period of six years. The study was originally designed as a randomized trial which had to be changed into a prospective observation study. A high therapeutic standard was guaranteed by quality control. The univariate analysis of prognostic variables was the first step to a valid treatment comparison. Those factors determined as being significant were combined with the treatment effects in a multivariate analysis. The published results were obtained after a median observation time of four years.
Publication types
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Clinical Trial
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English Abstract
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Multicenter Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Breast Neoplasms / mortality
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Breast Neoplasms / pathology
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Breast Neoplasms / radiotherapy
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Breast Neoplasms / surgery*
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Combined Modality Therapy
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Female
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Follow-Up Studies
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Humans
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Lymphatic Metastasis
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Mastectomy, Segmental / methods*
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Middle Aged
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Neoplasm Staging
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Neoplasms, Hormone-Dependent / mortality
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Neoplasms, Hormone-Dependent / pathology
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Neoplasms, Hormone-Dependent / surgery
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Prospective Studies
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Radiotherapy Dosage
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Receptors, Estrogen / analysis
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Receptors, Progesterone / analysis
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Survival Rate
Substances
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Receptors, Estrogen
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Receptors, Progesterone