Myopathy associated with HMG-CoA reductase inhibitors (HMGRIs) and cyclosporin A: evaluation in a rat model

MeSH terms

• Animals
• Anticholesteremic Agents / pharmacokinetics
• Anticholesteremic Agents / toxicity*
• Cyclosporine / pharmacokinetics
• Cyclosporine / toxicity*
• Drug Synergism
• Female
• Hydroxymethylglutaryl-CoA Reductase Inhibitors*
• Lovastatin / analogs & derivatives
• Lovastatin / pharmacokinetics
• Lovastatin / toxicity
• Muscles / drug effects
• Muscles / pathology
• Muscular Diseases / blood
• Muscular Diseases / chemically induced*
• Muscular Diseases / pathology
• Necrosis
• Pravastatin / pharmacokinetics
• Pravastatin / toxicity
• Rats
• Rats, Inbred Strains
• Simvastatin
• Structure-Activity Relationship