Abstract
Three new isoflavonoids, named millewanins G (1) and H (2) and furowanin B (3), were isolated from the leaves of Millettia pachycarpa. Their structures were elucidated on the basis of spectroscopic analyses. The antiestrogenic activity in the yeast two-hybrid assay of these isoflavonoids was examined and shown to be comparable with that of 4-hydroxytamoxifen.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Estrogen Receptor Modulators* / chemistry
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Estrogen Receptor Modulators* / isolation & purification
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Estrogen Receptor Modulators* / pharmacology
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Isoflavones* / chemistry
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Isoflavones* / isolation & purification
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Isoflavones* / pharmacology
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Japan
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Millettia / chemistry*
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Molecular Structure
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Plants, Medicinal / chemistry*
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Yeasts / drug effects
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beta-Galactosidase / antagonists & inhibitors
Substances
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Estrogen Receptor Modulators
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Isoflavones
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furowanin B
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millewanin G
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millewanin H
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beta-Galactosidase