Abstract
We identified two regulators of denitrification genes in Brucella melitensis 16M: NarR, which regulates the nitrate reductase (nar) operon, and NnrA, which is involved in the expression of the last three reductases of the denitrification pathway (nirK, norB, and nosZ). NnrA is required for virulence in mice and for intracellular resistance to nitric oxide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Proteins / genetics*
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Brucella melitensis / genetics*
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Brucella melitensis / pathogenicity
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Brucellosis / microbiology
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Gene Expression Regulation, Bacterial*
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Genes, Bacterial*
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Mice
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Nitrate Reductase / genetics*
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Nitric Oxide
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Operon
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Virulence / genetics
Substances
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Bacterial Proteins
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Nitric Oxide
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Nitrate Reductase