Allelic variation of a functional polymorphism in the serotonin transporter gene and depression in Parkinson's disease

David J Burn; Watcharee Tiangyou; Liesl M Allcock; Jill Davison; Patrick F Chinnery

doi:10.1016/j.parkreldis.2005.11.005

Allelic variation of a functional polymorphism in the serotonin transporter gene and depression in Parkinson's disease

Parkinsonism Relat Disord. 2006 Apr;12(3):139-41. doi: 10.1016/j.parkreldis.2005.11.005. Epub 2006 Feb 3.

Authors

David J Burn¹, Watcharee Tiangyou, Liesl M Allcock, Jill Davison, Patrick F Chinnery

Affiliation

¹ Department of Neurology, University of Newcastle upon Tyne, UK. [email protected]

PMID: 16459126
DOI: 10.1016/j.parkreldis.2005.11.005

Abstract

A genetic susceptibility to depression in PD, acting via the serotonergic system, has been suggested. We examined the influence of allelic variation (L/S) in a functional polymorphism in the serotonin transporter (5-HTTLPR) gene upon mood in 108 PD patients and 82 controls. Using a logistic regression model we found no evidence for an association between 5-HTTLPR genotypes, or the presence of the S allele, and depression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alleles
Depression / epidemiology
Depression / genetics*
Female
Genetic Predisposition to Disease / epidemiology
Genetic Variation
Humans
Logistic Models
Male
Middle Aged
Parkinson Disease / epidemiology
Parkinson Disease / genetics*
Polymorphism, Genetic*
Promoter Regions, Genetic / genetics
Risk Factors
Serotonin Plasma Membrane Transport Proteins / genetics*

Substances

Serotonin Plasma Membrane Transport Proteins