Abstract
Here we report that Caenorhabditis elegans nematodes fed Listeria monocytogenes die over the course of several days, as a consequence of an accumulation of bacteria in the worm intestine. Mutant strains previously shown to be important for virulence in mammalian models were also found to be attenuated in their virulence in C. elegans. However, ActA, which is required for actin-based intracellular motility, appears to be dispensable during infection of C. elegans, indicating that L. monocytogenes remains extracellular in C. elegans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology
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Caenorhabditis elegans / microbiology*
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Digestive System / microbiology
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Escherichia coli / pathogenicity
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Listeria monocytogenes / genetics
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Listeria monocytogenes / pathogenicity*
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Listeria monocytogenes / physiology
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Membrane Proteins / genetics
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Membrane Proteins / physiology
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Models, Biological
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Mutation
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Virulence / genetics
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Virulence / physiology
Substances
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Bacterial Proteins
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Membrane Proteins
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actA protein, Listeria monocytogenes