Treatment of HCV infection with interferon alpha-2b and ribavirin in a patient with X-linked lymphoproliferative syndrome

Nicola Strnad-Trojan; Richard Linde; Janine Reichenbach; Jörg Trojan; Stefan Zeuzem; Stefan Zielen

doi:10.1007/s00431-005-0062-3

Treatment of HCV infection with interferon alpha-2b and ribavirin in a patient with X-linked lymphoproliferative syndrome

Eur J Pediatr. 2006 May;165(5):348-50. doi: 10.1007/s00431-005-0062-3. Epub 2006 Feb 4.

Authors

Nicola Strnad-Trojan¹, Richard Linde, Janine Reichenbach, Jörg Trojan, Stefan Zeuzem, Stefan Zielen

Affiliation

¹ Department of Paediatrics, Johann Wolfgang Goethe University Medical Centre, Frankfurt am Main, Germany. [email protected]

PMID: 16463052
DOI: 10.1007/s00431-005-0062-3

Abstract

Chronic hepatitis C (HCV) infection in patients with primary immunodeficiency increases the risk of an accelerated progression of HCV-related liver disease. Here, we report a patient with X-linked lymphoproliferative syndrome infected with HCV and Epstein-Barr virus (EBV). After combination treatment with interferon alpha-2b and ribavirin, clearance of HCV-RNA was achieved, and noteworthily, EBV DNA also became undetectable.

Publication types

Case Reports

MeSH terms

Antiviral Agents / therapeutic use*
Child
DNA, Viral / analysis
Drug Therapy, Combination
Epstein-Barr Virus Infections / complications
Epstein-Barr Virus Infections / drug therapy
Hepatitis C, Chronic / complications
Hepatitis C, Chronic / drug therapy*
Humans
Interferon alpha-2
Interferon-alpha / therapeutic use*
Lymphoproliferative Disorders / complications*
RNA, Viral / analysis
Recombinant Proteins
Ribavirin / therapeutic use*

Substances

Antiviral Agents
DNA, Viral
Interferon alpha-2
Interferon-alpha
RNA, Viral
Recombinant Proteins
Ribavirin