Simple protocol for NMR analysis of the enantiomeric purity of primary amines

Yolanda Pérez-Fuertes; Andrew M Kelly; Andrew L Johnson; Susumu Arimori; Steven D Bull; Tony D James

doi:10.1021/ol052776g

Simple protocol for NMR analysis of the enantiomeric purity of primary amines

Org Lett. 2006 Feb 16;8(4):609-12. doi: 10.1021/ol052776g.

Authors

Yolanda Pérez-Fuertes¹, Andrew M Kelly, Andrew L Johnson, Susumu Arimori, Steven D Bull, Tony D James

Affiliation

¹ Department of Chemistry, University of Bath, Bath, BA2 7AY, UK.

PMID: 16468723
DOI: 10.1021/ol052776g

Abstract

[reaction: see text] A practically simple three-component chiral derivatizing protocol for determining the enantiopurity of 13 chiral primary amines by (1)H NMR spectroscopic analysis is described, including analysis of those that contain remote stereocenters.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / analysis*
Amines / chemistry*
Magnetic Resonance Spectroscopy / methods*
Molecular Structure
Stereoisomerism

Substances

Amines