Abstract
[structure: see text] An Australian isolate of the soil ascomycete Gymnoascus reessii yielded a series of cytotoxic metabolites, including the known polyenylpyrroles rumbrin (1) and auxarconjugatin A (2), and the new rumbrin stereoisomer 12E-isorumbrin (3), as well as an unprecedented class of polyenylfurans exemplified by gymnoconjugatins A (4) and B (5). Structures were assigned with detailed spectroscopic analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Ascomycota / chemistry*
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Australia
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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Humans
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Molecular Structure
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Pyrones / chemistry*
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Pyrones / isolation & purification*
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Pyrones / pharmacology
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Pyrroles / chemistry*
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Pyrroles / isolation & purification*
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Pyrroles / pharmacology
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Soil Microbiology*
Substances
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Antineoplastic Agents
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Furans
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Pyrones
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Pyrroles
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auxarconjugatin A
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gymnoconjugatin A
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gymnoconjugatin B
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rumbrin