Abstract
The genetic variability within PT/SAP, LYP and LXXLF HIV-1 P6gag motifs, required for the binding to Tsg101 and AIP1 cellular host proteins during viral budding, was examined in 122 HIV-infected subjects. PT/SAP duplications were statistically more frequent in B versus non-B subtypes. Substitutions at LYP were fourfold less frequent in antiretroviral-experienced only in clade B. P6gag variability across HIV-1 subtypes and after antiretroviral exposure may influence interactions with host cells involved in viral budding.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing
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Binding Sites
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Carrier Proteins
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DNA-Binding Proteins / metabolism
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Endosomal Sorting Complexes Required for Transport
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Gene Products, gag / genetics*
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Genetic Variation
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Guanylate Kinases
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HIV Infections / genetics*
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HIV-1 / genetics*
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HIV-1 / physiology
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Humans
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Mutation / genetics
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Proteins / metabolism
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Transcription Factors / metabolism
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Virus Replication / physiology
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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DNA-Binding Proteins
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Endosomal Sorting Complexes Required for Transport
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Gene Products, gag
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Proteins
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Transcription Factors
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Tsg101 protein
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Guanylate Kinases
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MAGI2 protein, human