Abstract
Twenty dogs with otitis externa in both ears and numerous Malassezia species yeasts on cytological examination were treated in one ear with a combination product containing clotrimazole, marbofloxacin and dexamethasone, and in the other ear with a topical antifungal containing miconazole. The effects of the treatments were analysed on the basis of the scores for pruritus, erythema and amount of cerumen, and the number of yeasts on cytological smears. There were reductions in the counts of Malassezia species after both treatments, but the combination product gave significantly greater reductions in erythema, cerumen and pruritus.
MeSH terms
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Administration, Topical
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Adrenal Cortex Hormones / administration & dosage
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Adrenal Cortex Hormones / therapeutic use*
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use*
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Antifungal Agents / administration & dosage
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Antifungal Agents / therapeutic use*
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Chi-Square Distribution
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Clotrimazole / administration & dosage
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Clotrimazole / therapeutic use
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Dermatomycoses / drug therapy
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Dermatomycoses / veterinary
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Dexamethasone / administration & dosage
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Dexamethasone / therapeutic use
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Dog Diseases / drug therapy*
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Dog Diseases / microbiology
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Dogs
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Drug Combinations
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Female
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Fluoroquinolones / administration & dosage
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Fluoroquinolones / therapeutic use
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Malassezia / pathogenicity*
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Male
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Miconazole / administration & dosage
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Miconazole / therapeutic use
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Otitis Externa / drug therapy
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Otitis Externa / microbiology
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Otitis Externa / veterinary*
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Quinolones / administration & dosage
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Quinolones / therapeutic use
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Treatment Outcome
Substances
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Adrenal Cortex Hormones
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Anti-Bacterial Agents
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Antifungal Agents
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Drug Combinations
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Fluoroquinolones
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Quinolones
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Miconazole
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Dexamethasone
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marbofloxacin
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Clotrimazole